Something from Alzheimer’s Disease and a Root-Cause Approach
Jan 07, 2026
Conventional treatment models have historically emphasized symptom control, often overlooking the underlying biological processes that drive neuronal damage.
Dr. Link approaches Alzheimer’s and cognitive decline through the PNI (Psycho-Neuro-Immunology) protocol, an integrative framework designed to identify and correct the systemic contributors to neurodegeneration—particularly inflammation, metabolic dysfunction, immune dysregulation, and mitochondrial damage.
The PNI protocol is personalized, data-driven, and multi-pathway focused. It does not rely on a one-size-fits-all model. Instead, it evaluates each patient’s unique biochemical, genetic, metabolic, and lifestyle profile to construct a targeted therapeutic plan.
This approach addresses the biological terrain in which neurodegeneration develops, rather than isolating the brain from the rest of the body.
Metabolic and environmental toxins contribute directly to neuroinflammation and impaired glucose regulation—both of which are toxic to brain tissue.
Patients undergoing the PNI protocol eliminate major inflammatory and neurotoxic dietary inputs, including:
Refined sugars and excess carbohydrates
Gluten and processed grains
Industrial seed and vegetable oils
Processed foods and fructose
Dairy, lectins, and other inflammatory triggers
As Dr. Link explains:
“Neuroinflammation enters the mitochondria and damages it. Once mitochondrial integrity is lost, neurons begin to fail. Plaques and precursor proteins accumulate as a consequence. By removing toxins and inflammation, the brain—like other tissues—retains the capacity to heal.”
Each patient undergoes a comprehensive assessment that may include:
Genetic and metabolic profiling
Inflammatory and immune markers
Hormonal evaluation
Cardiometabolic risk factors
The protocol prioritizes stabilization of systemic conditions that impair brain recovery, including hypertension, insulin resistance, dyslipidemia, and chronic inflammatory states.
Dr. Link emphasizes:
“The brain can heal—but not while it is being continuously irritated or damaged. Conditions such as diabetes, hypertension, dyslipidemia, and even certain medications interfere directly with neural repair.”
A central pillar of the PNI protocol is restoring the gut-brain axis. The gut microbiome plays a critical role in inflammation regulation, neurotransmitter production, mood, and cognitive resilience.
“The gut-brain connection is not theoretical. Microbiota influence—and are found within—brain tissue. Optimizing the microbiome is foundational to neurological healing.”
Additional therapeutic elements include:
Short-term, supervised water fasting to induce endogenous ketone production
Nutritional strategies (often ketogenic or plant-focused) to reduce inflammation and support neuronal energy metabolism
Individually tailored physical activity to enhance cerebral blood flow
Stress-reduction techniques and structured sleep optimization to support neuroplasticity and repair
Targeted supplementation is used to correct deficiencies, support mitochondrial function, and reinforce neurological resilience. Within this context, Res-Q Natural Supplements may be incorporated to complement the protocol:
Res-Q Ultimate B Complex – supports neurotransmitter synthesis, methylation, and neural energy metabolism
Res-Q ProBiotic – promotes gut-brain axis balance and inflammation control
Res-Q CellPower with CoQ10 – supports mitochondrial health and protects against oxidative neuronal damage
Res-Q PM – promotes restorative sleep critical for memory consolidation and brain repair
Res-Q Stress Blocker – supports stress resilience and cognitive clarity through adaptogenic compounds
Res-Q Brain Focus – includes phosphatidylserine and other compounds essential for neuronal membrane integrity and cognitive performance
Dr. Gianna Link views the PNI protocol as a natural, systems-oriented approach to cognitive decline—one that respects the brain as part of an integrated biological network. By addressing inflammation, metabolism, immunity, and lifestyle simultaneously, the protocol aims not merely to slow decline, but to restore the conditions necessary for neurological healing and resilience.
This integrative philosophy reflects Dr. Link’s lifelong commitment to advancing neurological care through science-driven, patient-specific medicine.